The BFlow team, in collaboration with the Novos Materiais Group (CINTECX), led by principal investigator Pio Manuel González Fernández, has developed an advanced dynamic model for the study of bone regeneration. This work was presented at the II Workshop on Additive Biofabrication (WAB 2026) in Santiago de Compostela by Miriam López Álvarez.

The work focuses on an Organ-on-a-chip system that integrates a three-dimensional scaffold within a microfluidic platform, with the aim of more realistically reproducing the bone microenvironment in vitro. This approach allows for the combination of 3D architecture, dynamic perfusion and control of physical-chemical parameters, key factors for the study of osteogenic differentiation and extracellular matrix formation.

The scaffold was manufactured using additive biofabrication techniques, allowing precise control of porosity, interconnectivity and mechanical properties, critical parameters for guiding cellular response. Integration with microfluidics facilitates the application of mechanical stimuli and the continuous supply of nutrients, improving the physiological relevance of the model compared to conventional static cultures.

The system was developed mainly by Serxio Álvarez Olcina, who completed his master’s internship and final master’s project at BFlow, contributing to the design, manufacture and experimental implementation of the platform.

These types of dynamic models represent a promising tool for evaluating biomaterials, studying bone tissue engineering strategies, and developing more predictive in vitro systems, thereby helping to reduce dependence on animal models in preclinical research